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Noncanonical IFN Signaling: Mechanistic Linkage of Genetic and Epigenetic Events

The canonical model of cytokine signaling via the JAK/STAT pathway dominates our view of signal transduction but provides no insight into the significance of the simultaneous presence of activated JAKs and STATs in the nucleus of cells treated with cytokines. Such a mechanistic shortcoming challenge...

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Detalhes bibliográficos
Publicado no:Mediators Inflamm
Main Authors: Johnson, Howard M., Ahmed, Chulbul M.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5203919/
https://ncbi.nlm.nih.gov/pubmed/28077919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/9564814
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