Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block

BACKGROUND: Drugs that prolong the heart rate corrected QT interval (QTc) on the electrocardiogram (ECG) by blocking the hERG potassium channel and also block inward currents (late sodium or L-type calcium) are not associated with torsade de pointes (e.g. ranolazine and verapamil). Thus, identifying...

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Foilsithe in:PLoS One
Main Authors: Vicente, Jose, Johannesen, Lars, Hosseini, Meisam, Mason, Jay W., Sager, Philip T., Pueyo, Esther, Strauss, David G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2016
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201270/
https://ncbi.nlm.nih.gov/pubmed/28036334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163619
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