A Sema3C Mutant Resistant to Cleavage by Furin (FR-Sema3C) Inhibits Choroidal Neovascularization

In age-related macular degeneration (AMD), abnormal sub retinal choroidal neovascularization (CNV) is a major cause of blindness. FR-sema3C is a point mutated form of semaphorin-3C that is resistant to cleavage by furin like pro-protein convertases (FPPC). We have found in previous work that FR-sema...

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Publicat a:PLoS One
Autors principals: Toledano, Shira, Lu, Huayi, Palacio, Agustina, Ziv, Keren, Kessler, Ofra, Schaal, Shlomit, Neufeld, Gera, Barak, Yoreh
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201251/
https://ncbi.nlm.nih.gov/pubmed/28036336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168122
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