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Loss of the tumor suppressor BAP1 causes myeloid transformation
Deubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur in various malignancies. We show that mouse Bap1 gene deletion is lethal during embryogenesis, but systemic or hematopoietic-restricted deletio...
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| Publicado en: | Science |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5201002/ https://ncbi.nlm.nih.gov/pubmed/22878500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1221711 |
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