Calcium and cAMP activate different chloride channels in the apical membrane of normal and cystic fibrosis epithelia.
The genetic disease cystic fibrosis (CF) causes decreased Cl- transport in several epithelia. cAMP-dependent regulation of apical membrane Cl- channels is defective in CF airway epithelia; as a result, CF epithelia fail to secrete Cl-. In contrast, Ca(2+)-stimulated Cl- secretion is intact in CF air...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1991
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52010/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1712478/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.14.6003 |
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