Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells

Gastric cancer (GC) is characterized by amplifications of receptor tyrosine kinases (RTK) and KRAS, therefore, targeting of the RTK/KRAS downstream pathways could help to broaden the applicability of molecular targeted therapy for GC. We assembled a panel of 48 GC cell lines and screened predictors...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Hirashita, Yuka, Tsukamoto, Yoshiyuki, Yanagihara, Kazuyoshi, Fumoto, Shoichi, Hijiya, Naoki, Nakada, Chisato, Uchida, Tomohisa, Matsuura, Keiko, Kodama, Masaaki, Okimoto, Tadayoshi, Daa, Tsutomu, Seike, Masataka, Iha, Hidekatsu, Shirao, Kuniaki, Murakami, Kazunari, Moriyama, Masatsugu
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198963/
https://ncbi.nlm.nih.gov/pubmed/27699948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13094
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