G Protein–Coupled Receptor-G–Protein βγ–Subunit Signaling Mediates Renal Dysfunction and Fibrosis in Heart Failure

Development of CKD secondary to chronic heart failure (CHF), known as cardiorenal syndrome type 2 (CRS2), clinically associates with organ failure and reduced survival. Heart and kidney damage in CRS2 results predominantly from chronic stimulation of G protein–coupled receptors (GPCRs), including ad...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Kamal, Fadia A., Travers, Joshua G., Schafer, Allison E., Ma, Qing, Devarajan, Prasad, Blaxall, Burns C.
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2017
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198268/
https://ncbi.nlm.nih.gov/pubmed/27297948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015080852
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