Analytical Enantio-Separation of Linagliptin in Linagliptin and Metformin HCl Dosage Forms by Applying Two-Level Factorial Design

A novel, stability indicating, reverse phase high-performance liquid chromatography (RP-HPLC) method was developed to determine the S-isomer of linagliptin (LGP) in linagliptin and metformin hydrochloride (MET HCl) tablets (LGP–MET HCl) by implementing design of experiment (DoE), i.e., two-level, fu...

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Detalhes bibliográficos
Publicado no:Sci Pharm
Main Authors: Jadhav, Sushant B., Mane, Rahul M., Narayanan, Kalyanraman L., Bhosale, Popatrao N.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198026/
https://ncbi.nlm.nih.gov/pubmed/27763526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/scipharm84040671
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