The M(1) Muscarinic Receptor Antagonist VU0255035 Delays the Development of Status Epilepticus after Organophosphate Exposure and Prevents Hyperexcitability in the Basolateral Amygdala

Exposure to organophosphorus toxins induces seizures that progress to status epilepticus (SE), which can cause brain damage or death. Seizures are generated by hyperstimulation of muscarinic receptors, subsequent to inhibition of acetylcholinesterase; this is followed by glutamatergic hyperactivity,...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Miller, Steven L., Aroniadou-Anderjaska, Vassiliki, Pidoplichko, Volodymyr I., Figueiredo, Taiza H., Apland, James P., Krishnan, Jishnu K. S., Braga, Maria F. M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2017
Assuntos:
Neuropharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5193080/
https://ncbi.nlm.nih.gov/pubmed/27799295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.236125
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