Alginate Oligosaccharide Prevents Acute Doxorubicin Cardiotoxicity by Suppressing Oxidative Stress and Endoplasmic Reticulum-Mediated Apoptosis

Doxorubicin (DOX) is a highly potent chemotherapeutic agent, but its usage is limited by dose-dependent cardiotoxicity. DOX-induced cardiotoxicity involves increased oxidative stress and activated endoplasmic reticulum-mediated apoptosis. Alginate oligosaccharide (AOS) is a non-immunogenic, non-toxi...

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Publicado no:Mar Drugs
Main Authors: Guo, Jun-Jie, Ma, Lei-Lei, Shi, Hong-Tao, Zhu, Jian-Bing, Wu, Jian, Ding, Zhi-Wen, An, Yi, Zou, Yun-Zeng, Ge, Jun-Bo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192468/
https://ncbi.nlm.nih.gov/pubmed/27999379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md14120231
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