Substantial Targeting Advantage Achieved by Pulmonary Administration of Colistin Methanesulfonate in a Large-Animal Model

Colistin, administered as its inactive prodrug colistin methanesulfonate (CMS), is often used in multidrug-resistant Gram-negative pulmonary infections. The CMS and colistin pharmacokinetics in plasma and epithelial lining fluid (ELF) following intravenous and pulmonary dosing have not been evaluate...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Landersdorfer, Cornelia B., Nguyen, Tri-Hung, Lieu, Linh Thuy, Nguyen, Gary, Bischof, Robert J., Meeusen, Els N., Li, Jian, Nation, Roger L., McIntosh, Michelle P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192148/
https://ncbi.nlm.nih.gov/pubmed/27821445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01934-16
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