Competitive Growth Enhances Conditional Growth Mutant Sensitivity to Antibiotics and Exposes a Two-Component System as an Emerging Antibacterial Target in Burkholderia cenocepacia

Chemogenetic approaches to profile an antibiotic mode of action are based on detecting differential sensitivities of engineered bacterial strains in which the antibacterial target (usually encoded by an essential gene) or an associated process is regulated. We previously developed an essential-gene...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Gislason, April S., Choy, Matthew, Bloodworth, Ruhi A. M., Qu, Wubin, Stietz, Maria S., Li, Xuan, Zhang, Chenggang, Cardona, Silvia T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192132/
https://ncbi.nlm.nih.gov/pubmed/27799222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00790-16
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