Single-Cell-Based Analysis Highlights a Surge in Cell-to-Cell Molecular Variability Preceding Irreversible Commitment in a Differentiation Process

In some recent studies, a view emerged that stochastic dynamics governing the switching of cells from one differentiation state to another could be characterized by a peak in gene expression variability at the point of fate commitment. We have tested this hypothesis at the single-cell level by analy...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Richard, Angélique, Boullu, Loïs, Herbach, Ulysse, Bonnafoux, Arnaud, Morin, Valérie, Vallin, Elodie, Guillemin, Anissa, Papili Gao, Nan, Gunawan, Rudiyanto, Cosette, Jérémie, Arnaud, Ophélie, Kupiec, Jean-Jacques, Espinasse, Thibault, Gonin-Giraud, Sandrine, Gandrillon, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5191835/
https://ncbi.nlm.nih.gov/pubmed/28027290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002585
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