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New open conformation of SMYD3 implicates conformational selection and allostery
SMYD3 plays a key role in cancer cell viability, adhesion, migration and invasion. SMYD3 promotes formation of inducible regulatory T cells and is involved in reducing autoimmunity. However, the nearly “closed” substrate-binding site and poor in vitro H3K4 methyltransferase activity have obscured fu...
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| Publicado no: | AIMS Biophys |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5189988/ https://ncbi.nlm.nih.gov/pubmed/28050603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3934/biophy.2017.1.1 |
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