Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic Risk Scores

Nutrigenetic studies analyzing gene–diet interactions of the TCF7L2-rs7903146 C > T polymorphism on type-2 diabetes (T2D) have shown controversial results. A reason contributing to this may be the additional modulation by obesity. Moreover, TCF7L2-rs7903146 is one of the most influential variants...

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Vydáno v:Nutrients
Hlavní autoři: Corella, Dolores, Coltell, Oscar, Sorlí, Jose V., Estruch, Ramón, Quiles, Laura, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Castañer, Olga, Arós, Fernando, Ortega-Calvo, Manuel, Serra-Majem, Lluís, Gómez-Gracia, Enrique, Portolés, Olga, Fiol, Miquel, Díez Espino, Javier, Basora, Josep, Fitó, Montserrat, Ros, Emilio, Ordovás, José M.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5188448/
https://ncbi.nlm.nih.gov/pubmed/27929407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu8120793
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