A mucosally targeted subunit vaccine candidate eliciting HIV-1 transcytosis-blocking Abs

A vaccine that would engage the mucosal immune system against a broad range of HIV-1 subtypes and prevent epithelial transmission is highly desirable. Here we report fusing the mucosal targeting B subunit of cholera toxin to the conserved galactosylceramide-binding domain (including the ELDKWA-neutr...

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Autors principals: Matoba, Nobuyuki, Magérus, Aude, Geyer, Brian C., Zhang, Yunfang, Muralidharan, Mrinalini, Alfsen, Annette, Arntzen, Charles J., Bomsel, Morgane, Mor, Tsafrir S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC518798/
https://ncbi.nlm.nih.gov/pubmed/15347807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405297101
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