Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in either of the two tumor suppressor genes TSC1 or TSC2, which encode hamartin and tuberin, respectively. Tuberin and hamartin form a complex that inhibits signaling by the mammalian target of rapamycin (mTOR), a critical nu...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Roux, Philippe P., Ballif, Bryan A., Anjum, Rana, Gygi, Steven P., Blenis, John
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2004
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC518784/
https://ncbi.nlm.nih.gov/pubmed/15342917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405659101
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