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Segmental Aging Underlies the Development of a Parkinson Phenotype in the AS/AGU Rat

There is a paucity of information on the molecular biology of aging processes in the brain. We have used biomarkers of aging (SA β-Gal, p16(Ink4a), Sirt5, Sirt6, and Sirt7) to demonstrate the presence of an accelerated aging phenotype across different brain regions in the AS/AGU rat, a spontaneous P...

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Détails bibliographiques
Publié dans:Cells
Auteurs principaux: Khojah, Sohair M., Payne, Anthony P., McGuinness, Dagmara, Shiels, Paul G.
Format: Artigo
Langue:Inglês
Publié: MDPI 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187522/
https://ncbi.nlm.nih.gov/pubmed/27763519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells5040038
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