Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility

Testicular germ cell tumour (TGCT) is the most common cancer in young men. Here we sought to identify risk factors for TGCT by performing whole-exome sequencing on 328 TGCT cases from 153 families, 634 sporadic TGCT cases and 1,644 controls. We search for genes that are recurrently affected by rare...

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Foilsithe in:Nat Commun
Main Authors: Litchfield, Kevin, Levy, Max, Dudakia, Darshna, Proszek, Paula, Shipley, Claire, Basten, Sander, Rapley, Elizabeth, Bishop, D. Timothy, Reid, Alison, Huddart, Robert, Broderick, Peter, Castro, David Gonzalez de, O'Connor, Simon, Giles, Rachel H., Houlston, Richard S., Turnbull, Clare
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2016
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187424/
https://ncbi.nlm.nih.gov/pubmed/27996046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13840
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