Optimized Cocktail Phenotyping Study Protocol Using Physiological Based Pharmacokinetic Modeling and In silico Assessment of Metabolic Drug–Drug Interactions Involving Modafinil

In vivo cocktail pathway phenotyping (ICPP) is routinely used to assess the metabolic drug–drug interaction (mDDI) potential of new drug candidates (NDC) during drug development. However, there are a number of potential limitations to this approach and the use of validated drug cocktails and study p...

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Vydáno v:Front Pharmacol
Hlavní autoři: Rowland, Angela, Mangoni, Arduino A., Hopkins, Ashley, Sorich, Michael J., Rowland, Andrew
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2016
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5186771/
https://ncbi.nlm.nih.gov/pubmed/28082902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00517
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