Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy

Spinal muscular atrophy (SMA) is a neuromuscular disease caused by low levels of SMN protein, primarily affecting lower motor neurons. Recent evidence from SMA and related conditions suggests that glial cells can influence disease severity. Here, we investigated the role of glial cells in the periph...

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Foilsithe in:Hum Mol Genet
Main Authors: Hunter, Gillian, Powis, Rachael A., Jones, Ross A., Groen, Ewout J.N., Shorrock, Hannah K., Lane, Fiona M., Zheng, Yinan, Sherman, Diane L., Brophy, Peter J., Gillingwater, Thomas H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2016
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5181642/
https://ncbi.nlm.nih.gov/pubmed/27170316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw141
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