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Oxygen consumption deficit in Huntington disease mouse brain under metabolic stress
In vivo evidence for brain mitochondrial dysfunction in animal models of Huntington disease (HD) is scarce. We applied the novel (17)O magnetic resonance spectroscopy (MRS) technique on R6/2 mice to directly determine rates of oxygen consumption (CMRO(2)) and assess mitochondrial function in vivo. B...
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| Publicado no: | Hum Mol Genet |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5181641/ https://ncbi.nlm.nih.gov/pubmed/27193167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw138 |
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