Perturb-seq: Dissecting molecular circuits with scalable single cell RNA profiling of pooled genetic screens

Genetic screens help infer gene function in mammalian cells, but it has remained difficult to assay complex phenotypes – such as transcriptional profiles – at scale. Here, we develop Perturb-seq, combining single cell RNA-seq and CRISPR based perturbations to perform many such assays in a pool. We d...

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書誌詳細
出版年:Cell
主要な著者: Dixit, Atray, Parnas, Oren, Li, Biyu, Chen, Jenny, Fulco, Charles P., Jerby-Arnon, Livnat, Marjanovic, Nemanja D., Dionne, Danielle, Burks, Tyler, Raychndhury, Raktima, Adamson, Britt, Norman, Thomas M., Lander, Eric S., Weissman, Jonathan S., Friedman, Nir, Regev, Aviv
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5181115/
https://ncbi.nlm.nih.gov/pubmed/27984732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.11.038
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