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Cyclooxygenase-2 deficiency impairs muscle-derived stem cell-mediated bone regeneration via cellular autonomous and non-autonomous mechanisms

This study investigated the role of cyclooxygenase-2 (COX-2) expression by donor and host cells in muscle-derived stem cell (MDSC)-mediated bone regeneration utilizing a critical size calvarial defect model. We found that BMP4/green fluorescent protein (GFP)-transduced MDSCs formed significantly les...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Gao, Xueqin, Usas, Arvydas, Lu, Aiping, Kozemchak, Adam, Tang, Ying, Poddar, Minakshi, Sun, Xuying, Cummins, James H., Huard, Johnny
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5179923/
https://ncbi.nlm.nih.gov/pubmed/27354351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw172
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