T cell–mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis

Clinical and histologic similarities between various eczematous disorders point to a common efferent pathway. We demonstrate here that activated T cells infiltrating the skin in atopic dermatitis (AD) and allergic contact dermatitis (ACD) induce keratinocyte (KC) apoptosis. KCs normally express low...

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Autori principali: Trautmann, Axel, Akdis, Mübeccel, Kleemann, Daniela, Altznauer, Frank, Simon, Hans-Uwe, Graeve, Thomas, Noll, Michaela, Bröcker, Eva-B., Blaser, Kurt, Akdis, Cezmi A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC517909/
https://ncbi.nlm.nih.gov/pubmed/10880045
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