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Enhancing Mn(II)-binding and manganese peroxidase activity in a designed cytochrome c peroxidase through fine-tuning secondary sphere interactions
Non-covalent second shell interactions are important in controlling metal-binding affinity and activity in metalloenzymes, but fine-tuning these interactions in designed metalloenzymes has not been fully explored. As a result, most designed metalloenzymes have low metal-binding affinity and activity...
Gorde:
| Argitaratua izan da: | Biochemistry |
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| Egile Nagusiak: | , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2016
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5178831/ https://ncbi.nlm.nih.gov/pubmed/26885726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01299 |
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