Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity

Fungal infections are major causes of morbidity and mortality, especially in immunocompromised individuals. The innate immune system senses fungal pathogens through Syk-coupled C-type lectin receptors (CLRs), which signal through the conserved immune adaptor Card9. Although Card9 is essential for an...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Roth, Susanne, Bergmann, Hanna, Jaeger, Martin, Yeroslaviz, Assa, Neumann, Konstantin, Koenig, Paul-Albert, Prazeres da Costa, Clarissa, Vanes, Lesley, Kumar, Vinod, Johnson, Melissa, Menacho-Márquez, Mauricio, Habermann, Bianca, Tybulewicz, Victor L., Netea, Mihai, Bustelo, Xosé R., Ruland, Jürgen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5177621/
https://ncbi.nlm.nih.gov/pubmed/27926862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.11.018
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