Repeat exposure to group A streptococcal M protein exacerbates cardiac damage in a rat model of rheumatic heart disease

Rheumatic fever and rheumatic heart disease (RF/RHD) develop following repeated infection with group A streptococci (GAS). We used the Rat Autoimmune Valvulitis (RAV) model of RF/RHD to demonstrate that repetitive booster immunization with GAS-derived recombinant M protein (rM5) resulted in an enhan...

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Detalhes bibliográficos
Publicado no:Autoimmunity
Main Authors: Gorton, Davina, Sikder, Suchandan, Williams, Natasha L, Chilton, Lisa, Rush, Catherine M, Govan, Brenda L, Cunningham, Madeleine W, Ketheesan, Natkunam
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5177596/
https://ncbi.nlm.nih.gov/pubmed/27562362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/08916934.2016.1217999
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