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Repeat exposure to group A streptococcal M protein exacerbates cardiac damage in a rat model of rheumatic heart disease
Rheumatic fever and rheumatic heart disease (RF/RHD) develop following repeated infection with group A streptococci (GAS). We used the Rat Autoimmune Valvulitis (RAV) model of RF/RHD to demonstrate that repetitive booster immunization with GAS-derived recombinant M protein (rM5) resulted in an enhan...
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| Опубликовано в: : | Autoimmunity |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5177596/ https://ncbi.nlm.nih.gov/pubmed/27562362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/08916934.2016.1217999 |
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