Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia

Cure rates of children and adults with acute myeloid leukaemia (AML) remain unsatisfactory partly due to chemotherapy resistance. We investigated the genetic basis of AML in 107 primary cases by sequencing 670 genes mutated in haematological malignancies. SETBP1, ASXL1 and RELN mutations were signif...

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Detalhes bibliográficos
Publicado no:Br J Haematol
Main Authors: Brown, Fiona C., Cifani, Paolo, Drill, Esther, He, Jie, Still, Eric, Zhong, Shan, Balasubramanian, Sohail, Pavlick, Dean, Yilmazel, Bahar, Knapp, Kristina M., Alonzo, Todd A., Meshinchi, Soheil, Stone, Richard M., Kornblau, Steven M., Marcucci, Guido, Gamis, Alan S., Byrd, John C., Gonen, Mithat, Levine, Ross L., Kentsis, Alex
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5177472/
https://ncbi.nlm.nih.gov/pubmed/27766616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.14413
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