Role of Occult and Post-acute Phase Replication in Protective Immunity Induced with a Novel Live Attenuated SIV Vaccine

In order to evaluate the role of persisting virus replication during occult phase immunisation in the live attenuated SIV vaccine model, a novel SIVmac239Δnef variant (SIVrtTA) genetically engineered to replicate in the presence of doxycycline was evaluated for its ability to protect against wild-ty...

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Detalles Bibliográficos
Publicado en:PLoS Pathog
Autores principales: Berry, Neil, Manoussaka, Maria, Ham, Claire, Ferguson, Deborah, Tudor, Hannah, Mattiuzzo, Giada, Klaver, Bep, Page, Mark, Stebbings, Richard, Das, Atze T., Berkhout, Ben, Almond, Neil, Cranage, Martin P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5176322/
https://ncbi.nlm.nih.gov/pubmed/28002473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006083
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