Structural basis of actin sequestration by thymosin-β4: implications for WH2 proteins

The WH2 (Wiscott–Aldridge syndrome protein homology domain 2) repeat is an actin interacting motif found in monomer sequestering and filament assembly proteins. We have stabilized the prototypical WH2 family member, thymosin-β4 (Tβ4), with respect to actin, by creating a hybrid between gelsolin doma...

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Detalhes bibliográficos
Main Authors: Irobi, Edward, Aguda, Adeleke H, Larsson, Mårten, Guerin, Christophe, Yin, Helen L, Burtnick, Leslie D, Blanchoin, Laurent, Robinson, Robert C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC517612/
https://ncbi.nlm.nih.gov/pubmed/15329672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600372
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