Randomized, Open-Label, Phase 1/2a Study to Determine the Maximum Tolerated Dose of Intraventricular Sustained Release Nimodipine for Subarachnoid Hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage])

BACKGROUND AND PURPOSE—: We conducted a randomized, open-label, phase 1/2a, dose-escalation study of intraventricular sustained-release nimodipine (EG-1962) to determine safety, tolerability, pharmacokinetics, and clinical effects in aneurysmal subarachnoid hemorrhage. METHODS—: Subjects with aneury...

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Dettagli Bibliografici
Pubblicato in:Stroke
Autori principali: Hänggi, Daniel, Etminan, Nima, Aldrich, Francois, Steiger, Hans Jakob, Mayer, Stephan A., Diringer, Michael N., Hoh, Brian L., Mocco, J, Faleck, Herbert J., Macdonald, R. Loch
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lippincott Williams & Wilkins 2017
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Original Contributions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5176000/
https://ncbi.nlm.nih.gov/pubmed/27932607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.116.014250
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