A Calcium-Calmodulin Antagonist Blocks Experimental Vibrio vulnificus Cytolysin-Induced Lethality in an Experimental Mouse Model

We demonstrated that trifluoperazine, a calcium-calmodulin antagonist, blocked the hyperpermeability induced by Vibrio vulnificus cytolysin in in vitro-modeled endothelium and prevented the deaths of mice. Furthermore, compared to tetracycline alone, tetracycline combined with trifluoperazine enhanc...

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Detalhes bibliográficos
Main Authors: Lee, Young-Rae, Park, Kwang-Hyun, Lin, Zhao-Zhen, Kho, Young-Jong, Park, Jin-Woo, Rho, Hye-Won, Koo, Bon-Sun, Kim, Hyung-Rho, Song, Eun-Kyung, Yu, Hong-Nu, Han, Myung-Kwan, Lee, Seung-Ok, Jhee, Eun-Chung, Kim, Jong-Suk
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Bacterial Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC517569/
https://ncbi.nlm.nih.gov/pubmed/15385523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.10.6157-6159.2004
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