PCBP2 enables the cadicivirus IRES to exploit the function of a conserved GRNA tetraloop to enhance ribosomal initiation complex formation

The cadicivirus IRES diverges structurally from canonical Type 1 IRESs (e.g. poliovirus) but nevertheless also contains an essential GNRA tetraloop in a subdomain (d10c) that is homologous to poliovirus dIVc. In addition to canonical initiation factors, the canonical Type 1 and divergent cadicivirus...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Asnani, Mukta, Pestova, Tatyana V., Hellen, Christopher U.T.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175331/
https://ncbi.nlm.nih.gov/pubmed/27387282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw609
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