An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets

The IFIH1 gene encodes the pattern recognition receptor MDA5. A common polymorphism in IFIH1 (rs1990760, A946T) confers increased risk for autoimmune disease, including type 1-diabetes (T1D). Coxsackievirus infections are linked to T1D and cause beta-cell damage in vitro. Here we demonstrate that th...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Domsgen, Erna, Lind, Katharina, Kong, Lingjia, Hühn, Michael H., Rasool, Omid, van Kuppeveld, Frank, Korsgren, Olle, Lahesmaa, Riitta, Flodström-Tullberg, Malin
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175199/
https://ncbi.nlm.nih.gov/pubmed/28000722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39378
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