Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas

Pancreatic cancer is still a disease of high mortality despite availability of diagnostic techniques. Mucins (MUC) play crucial roles in carcinogenesis and tumor invasion in pancreatic neoplasms. MUC1 and MUC4 are high molecular weight transmembrane mucins. These are overexpressed in many carcinomas...

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Pubblicato in:Oncotarget
Autori principali: Yokoyama, Seiya, Higashi, Michiyo, Kitamoto, Sho, Oeldorf, Monika, Knippschild, Uwe, Kornmann, Marko, Maemura, Kosei, Kurahara, Hiroshi, Wiest, Edwin, Hamada, Tomofumi, Kitazono, Ikumi, Goto, Yuko, Tasaki, Takashi, Hiraki, Tsubasa, Hatanaka, Kazuhito, Mataki, Yuko, Taguchi, Hiroki, Hashimoto, Shinichi, Batra, Surinder K., Tanimoto, Akihide, Yonezawa, Suguru, Hollingsworth, Michael A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173155/
https://ncbi.nlm.nih.gov/pubmed/27283771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9924
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