The reverse-mode NCX1 activity inhibitor KB-R7943 promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux

We explored the effects of KB-R7943, an inhibitor of reverse-mode NCX1 activity, in prostate cancer (PCa). NCX1 was overexpressed in PCa tissues and cell lines, and higher NCX1 levels were associated higher PCa grades. At concentrations greater than 10 μM, KB-R7943 dose-dependently decreased PC3 and...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Long, Zhou, Chen, BaiJun, Liu, Qian, Zhao, Jiang, Yang, ZhenXing, Dong, XingYou, Xia, LiuBin, Huang, ShengQuan, Hu, XiaoYan, Song, Bo, Li, LongKun
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173116/
https://ncbi.nlm.nih.gov/pubmed/27275542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9806
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