microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway

microRNA-374a (miR-374a) exhibits oncogenic functions in various tumor types. Here we report that miR-374a suppresses proliferation, invasion, migration and intrahepatic metastasis in colon adenocarcinoma cell lines HCT116 and SW620. Notably, we detected that PI3K/AKT signaling and its downstream ce...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Chen, Yiyu, Jiang, Jingwen, Zhao, Mengyang, Luo, Xiaojun, Liang, Zixi, Zhen, Yan, Fu, Qiaofen, Deng, Xiaojie, Lin, Xian, Li, Libo, Luo, Rongcheng, Liu, Zhen, Fang, Weiyi
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173061/
https://ncbi.nlm.nih.gov/pubmed/27191497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9320
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