Protein kinase D-dependent CXCR4 down-regulation upon BCR triggering is linked to lymphadenopathy in chronic lymphocytic leukaemia

In Chronic Lymphocytic Leukemia (CLL), infiltration of lymph nodes by leukemic cells is observed in patients with progressive disease and adverse outcome. We have previously demonstrated that B-cell receptor (BCR) engagement resulted in CXCR4 down-regulation in CLL cells, correlating with a shorter...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Saint-Georges, Stéphane, Quettier, Maude, Bouyaba, Marouane, Le Coquil, Stéphanie, Laurienté, Vanessa, Guittat, Lionel, Lévy, Vincent, Ajchenbaum-Cymbalista, Florence, Varin-Blank, Nadine, Le Roy, Christine, Ledoux, Dominique
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173040/
https://ncbi.nlm.nih.gov/pubmed/27127886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9031
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