Protein kinase D-dependent CXCR4 down-regulation upon BCR triggering is linked to lymphadenopathy in chronic lymphocytic leukaemia

In Chronic Lymphocytic Leukemia (CLL), infiltration of lymph nodes by leukemic cells is observed in patients with progressive disease and adverse outcome. We have previously demonstrated that B-cell receptor (BCR) engagement resulted in CXCR4 down-regulation in CLL cells, correlating with a shorter...

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Foilsithe in:Oncotarget
Main Authors: Saint-Georges, Stéphane, Quettier, Maude, Bouyaba, Marouane, Le Coquil, Stéphanie, Laurienté, Vanessa, Guittat, Lionel, Lévy, Vincent, Ajchenbaum-Cymbalista, Florence, Varin-Blank, Nadine, Le Roy, Christine, Ledoux, Dominique
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2016
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173040/
https://ncbi.nlm.nih.gov/pubmed/27127886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9031
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