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Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation

Dendritic cells (DCs) have been implicated in the pathogenesis of psoriasis but the roles for specific DC subsets are not well defined. Here we show that DCs are required for psoriasis-like changes in mouse skin induced by the local injection of IL-23. However, Flt3L-dependent DCs and resident Lange...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Singh, Tej Pratap, Zhang, Howard H., Borek, Izabela, Wolf, Peter, Hedrick, Michael N., Singh, Satya P., Kelsall, Brian L., Clausen, Bjorn E., Farber, Joshua M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5171657/
https://ncbi.nlm.nih.gov/pubmed/27982014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13581
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