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Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation

Dendritic cells (DCs) have been implicated in the pathogenesis of psoriasis but the roles for specific DC subsets are not well defined. Here we show that DCs are required for psoriasis-like changes in mouse skin induced by the local injection of IL-23. However, Flt3L-dependent DCs and resident Lange...

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Pubblicato in:Nat Commun
Autori principali: Singh, Tej Pratap, Zhang, Howard H., Borek, Izabela, Wolf, Peter, Hedrick, Michael N., Singh, Satya P., Kelsall, Brian L., Clausen, Bjorn E., Farber, Joshua M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5171657/
https://ncbi.nlm.nih.gov/pubmed/27982014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13581
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