Regulation of breathing by CO(2) requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons

Blood gas and tissue pH regulation depend on the ability of the brain to sense CO(2) and/or H(+) and alter breathing appropriately, a homeostatic process called central respiratory chemosensitivity. We show that selective expression of the proton-activated receptor GPR4 in chemosensory neurons of th...

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Pubblicato in:Science
Autori principali: Kumar, Natasha N., Velic, Ana, Soliz, Jorge, Shi, Yingtang, Li, Keyong, Wang, Sheng, Weaver, Janelle L., Sen, Josh, Abbott, Stephen B.G., Lazarenko, Roman M., Ludwig, Marie-Gabrielle, Perez-Reyes, Edward, Mohebbi, Nilufar, Bettoni, Carla, Gassmann, Max, Suply, Thomas, Seuwen, Klaus, Guyenet, Patrice G., Wagner, Carsten A., Bayliss, Douglas A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5171229/
https://ncbi.nlm.nih.gov/pubmed/26068853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa0922
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