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Arl13b regulates Shh signaling from both inside and outside the cilium
The regulatory GTPase Arl13b localizes to primary cilia, where it regulates Sonic hedgehog (Shh) signaling. Missense mutations in ARL13B can cause the ciliopathy Joubert syndrome (JS), and the mouse null allele is embryonic lethal. We used mouse embryonic fibroblasts as a system to determine the eff...
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| Izdano u: | Mol Biol Cell |
|---|---|
| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The American Society for Cell Biology
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5170560/ https://ncbi.nlm.nih.gov/pubmed/27682584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-03-0189 |
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