The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K(+ )channels in the rat insulinoma cell line, CRI-G1

BACKGROUND: 3-guanidinopropionic acid derivatives reduce body weight in obese, diabetic mice. We have assessed whether one of these analogues, the aminoguanidine carboxylate BVT.12777, opens K(ATP )channels in rat insulinoma cells, by the same mechanism as leptin. RESULTS: BVT.12777 hyperpolarized C...

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Bibliographic Details
Main Authors: Kinsella, Jackie M, Laidlaw, Hilary A, Tang, Teresa, Harvey, Jenni, Sutherland, Calum, Ashford, Michael LJ
Format: Artigo
Language:Inglês
Published: BioMed Central 2004
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC516774/
https://ncbi.nlm.nih.gov/pubmed/15329154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2210-4-17
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