Histone Deacetylases 5 and 9 Govern Responsiveness of the Heart to a Subset of Stress Signals and Play Redundant Roles in Heart Development

The adult heart responds to stress signals by hypertrophic growth, which is often accompanied by activation of a fetal cardiac gene program and eventual cardiac demise. We showed previously that histone deacetylase 9 (HDAC9) acts as a suppressor of cardiac hypertrophy and that mice lacking HDAC9 are...

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Hlavní autoři: Chang, Shurong, McKinsey, Timothy A., Zhang, Chun Li, Richardson, James A., Hill, Joseph A., Olson, Eric N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2004
Témata:
Mammalian Genetic Models with Minimal or Complex Phenotypes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC516756/
https://ncbi.nlm.nih.gov/pubmed/15367668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.19.8467-8476.2004
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