Inactivation of the type I interferon pathway reveals long double‐stranded RNA‐mediated RNA interference in mammalian cells

RNA interference (RNAi) elicited by long double‐stranded (ds) or base‐paired viral RNA constitutes the major mechanism of antiviral defence in plants and invertebrates. In contrast, it is controversial whether it acts in chordates. Rather, in vertebrates, viral RNAs induce a distinct defence system...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Maillard, Pierre V, Van der Veen, Annemarthe G, Deddouche‐Grass, Safia, Rogers, Neil C, Merits, Andres, Reis e Sousa, Caetano
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167344/
https://ncbi.nlm.nih.gov/pubmed/27815315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695086
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