Chiral Brønsted Acid‐Catalyzed Enantioselective α‐Amidoalkylation Reactions: A Joint Experimental and Predictive Study

Enamides with a free NH group have been evaluated as nucleophiles in chiral Brønsted acid‐catalyzed enantioselective α‐amidoalkylation reactions of bicyclic hydroxylactams for the generation of quaternary stereocenters. A quantitative structure–reactivity relationship (QSRR) method has been develope...

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Publicat a:ChemistryOpen
Autors principals: Aranzamendi, Eider, Arrasate, Sonia, Sotomayor, Nuria, González‐Díaz, Humberto, Lete, Esther
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167290/
https://ncbi.nlm.nih.gov/pubmed/28032023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201600120
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