Niacin‐mediated Tace activation ameliorates CMT neuropathies with focal hypermyelination

Charcot–Marie–Tooth (CMT) neuropathies are highly heterogeneous disorders caused by mutations in more than 70 genes, with no available treatment. Thus, it is difficult to envisage a single suitable treatment for all pathogenetic mechanisms. Axonal Neuregulin 1 (Nrg1) type III drives Schwann cell mye...

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Publicat a:EMBO Mol Med
Autors principals: Bolino, Alessandra, Piguet, Françoise, Alberizzi, Valeria, Pellegatta, Marta, Rivellini, Cristina, Guerrero‐Valero, Marta, Noseda, Roberta, Brombin, Chiara, Nonis, Alessandro, D'Adamo, Patrizia, Taveggia, Carla, Previtali, Stefano Carlo
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167133/
https://ncbi.nlm.nih.gov/pubmed/27799291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201606349
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