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Targeting translation initiation bypasses signaling crosstalk mechanisms that maintain high MYC levels in colorectal cancer
Deregulated expression of MYC is a driver of colorectal carcinogenesis, suggesting that inhibiting MYC may have significant therapeutic value. The PI3-kinase and mTOR pathways control MYC turnover and translation, respectively, providing a rationale to target both pathways to inhibit MYC. Surprising...
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| 出版年: | Cancer Discov |
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| 主要な著者: | , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5166973/ https://ncbi.nlm.nih.gov/pubmed/25934076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-1040 |
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