Targeting translation initiation bypasses signaling crosstalk mechanisms that maintain high MYC levels in colorectal cancer

Deregulated expression of MYC is a driver of colorectal carcinogenesis, suggesting that inhibiting MYC may have significant therapeutic value. The PI3-kinase and mTOR pathways control MYC turnover and translation, respectively, providing a rationale to target both pathways to inhibit MYC. Surprising...

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Détails bibliographiques
Publié dans:Cancer Discov
Auteurs principaux: Wiegering, Armin, Uthe, Friedrich W., Jamieson, Thomas, Ruoss, Yvonne, Hüttenrauch, Melanie, Küspert, Maritta, Pfann, Christina, Nixon, Colin, Herold, Steffi, Walz, Susanne, Taranets, Lyudmyla, Germer, Christoph-Thomas, Rosenwald, Andreas, Sansom, Owen J, Eilers, Martin
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5166973/
https://ncbi.nlm.nih.gov/pubmed/25934076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-1040
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